CC49-streptavidin

A substance that is being studied in the treatment of cancer. It is made by combining the monoclonal antibody CC49 with a chemical called streptavidin. It can find tumor cells that have the protein TAG-72 on their surface, including colon, prostate, breast, and ovary cancer cells. After CC49-streptavidin binds to cancer cells, a radioactive compound called yttrium Y 90 DOTA-biotin will find those cells and kill them.

English dictionary of cancer terms . 2015.

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  • yttrium Y 90 DOTA-biotin — A compound that contains the radioisotope yttrium Y 90 linked to the chemical biotin. Biotin is a molecule that binds strongly to the chemical streptavidin. Yttrium Y 90 DOTA biotin will find tumor cells in the body that have been targeted by an… …   English dictionary of cancer terms

  • 90Y-DOTA-biotin — A compound that contains the radioisotope yttrium Y 90 linked to the chemical biotin. Biotin is a molecule that binds strongly to the chemical streptavidin. 90Y DOTA biotin will find tumor cells in the body that have been targeted by an antibody… …   English dictionary of cancer terms

  • 90Y-DOTA-biotin — consists of a radioactive substance (yttrium 90) complexed by a chelating agent (DOTA), which in turn is attached to the vitamin biotin via a chemical linker. It is used experimentally in pretargeted radioimmunotherapy. Animal studies have been… …   Wikipedia

  • DOTA (chelator) — DOTA IUPAC name 1,4,7,10 tetraazacyclododecane 1,4,7,10 tetraacetic acid …   Wikipedia

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