bispecific antibody

An antibody developed in the laboratory to recognize more than one protein on the surface of different cells. Examples include bispecific antibodies 2B1, 520C9xH22, mDX-H210, and MDX447.

English dictionary of cancer terms . 2015.

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  • bispecific antibody — antibody in which each of two antigen binding sites is specific for separate antigenic determinants. It is an artificial antibody produced in the laboratory, formed by reassociating half molecules of two different antibody specificities to form a …   Medical dictionary

  • Bispecific antibody — A bispecific antibody is a monoclonal antibodies which is designed to bind to two different antigens.One benefit of this approach is that it is possible for such an antibody to simultaneously bind to a cytotoxic cell (using a receptor like CD3)… …   Wikipedia

  • Bispecific monoclonal antibody — A bispecific monoclonal antibody is a monoclonal antibody that binds two different types of antigen. Bispecific monoclonal antibodies do not occur naturally; they must be made in the laboratory. External links *… …   Wikipedia

  • bispecific monoclonal antibody — A monoclonal antibody that binds two different types of antigen. Bispecific monoclonal antibodies do not occur naturally; they must be made in the laboratory …   English dictionary of cancer terms

  • bispecific — adjective Describing an antibody that binds to two different antigens …   Wiktionary

  • Monoclonal antibody therapy — Each antibody binds only one specific antigen. Monoclonal antibody therapy is the use of monoclonal antibodies (or mAb) to specifically bind to target cells or proteins. This may then stimulate the patient s immune system to attack those cells.… …   Wikipedia

  • hybrid antibody — bispecific a …   Medical dictionary

  • Single-domain antibody — Ribbon diagram of a llama VHH domain. The extended CDR3 loop is coloured orange. A single domain antibody (sdAb, called Nanobody by Ablynx, the developer[1]) is an antibody fragment consisting …   Wikipedia

  • Bispezifischer Antikörper — Ein bispezifischer Antikörper (Abkürzung: BsMAb von engl. bispecific monoclonal antibody), auch als Hybrid Antikörper bezeichnet, ist ein Immunkonjugat, das aus Bestandteilen von zwei unterschiedlichen monoklonalen Antikörpern aufgebaut sind.… …   Deutsch Wikipedia

  • Chemically linked Fab — Example of chemically linked Fabs: two Fab fragments linked with a thioether, resulting in a F(ab )2. The molecule is bound to a tumour cell via the tumour antigen CD30 and to a macrophage via an Fc receptor. Two chemically linked fragments… …   Wikipedia

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