recombinant tissue plasminogen activator

A form of tissue plasminogen activator that is made in the laboratory. It helps dissolve blood clots and is used to treat heart attacks, strokes, and clots in the lungs. It is also being studied in the treatment of cancer. It is a type of systemic thrombolytic agent. Also called r-tPA, Activase, and Alteplase.

English dictionary of cancer terms . 2015.

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  • Tissue plasminogen activator — (abbreviated tPA or PLAT) is a protein involved in the breakdown of blood clots. Specifically, it is a serine protease (EC number|3.4.21.68) found on endothelial cells, the cells that line the blood vessels. As an enzyme, it catalyzes the… …   Wikipedia

  • tissue plasminogen activator — n a clot dissolving enzyme that has an affinity for fibrin, that catalyzes the conversion of plasminogen to plasmin, that is produced naturally in blood vessel linings, and that is used in a genetically engineered form to prevent damage to heart… …   Medical dictionary

  • tissue plasminogen activator — n. an enzyme produced by the blood vessels that dissolves blood clots by converting plasminogen into plasmin: it is manufactured using recombinant DNA technology and used to prevent stroke, etc …   English World dictionary

  • Plasminogen activator inhibitor-2 — Serpin peptidase inhibitor, clade B (ovalbumin), member 2 PDB rendering based on 1by7 …   Wikipedia

  • activator — 1. A substance that renders another substance, or catalyst, active, or that accelerates a process or reaction. 2. The fragment, produced by chemical cleavage of a proactivator, that induces the enzymic activity of another …   Medical dictionary

  • List of recombinant proteins — Since human recombinants have replaced the animal version in human therapeutics, the prefix of rh for human recombinant appears less and less in the literatureHuman recombinants that largely replaced animal or harvested from human types*Human… …   Wikipedia

  • rTPA — recombinant tissue plasminogen activator …   Medical dictionary

  • rt-PA — recombinant tissue plasminogen activator …   Medical dictionary

  • rTPA — • recombinant tissue plasminogen activator …   Dictionary of medical acronyms & abbreviations

  • rt-PA — • recombinant tissue plasminogen activator …   Dictionary of medical acronyms & abbreviations

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