humanized monoclonal antibody

A type of antibody made in the laboratory by combining a human antibody with a small part of a mouse or rat monoclonal antibody. The mouse or rat part of the antibody binds to the target antigen, and the human part makes it less likely to be destroyed by the body's immune system.

English dictionary of cancer terms . 2015.

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  • maytansinoid DM4-conjugated humanized monoclonal antibody huC242 — A substance being studied in the treatment of some types of cancer. It is made by linking the monoclonal antibody huC242 to a toxic substance called maytansinoid DM4. The monoclonal antibody locates and binds to the surfaces of cancer cells and… …   English dictionary of cancer terms

  • Monoclonal antibody therapy — Each antibody binds only one specific antigen. Monoclonal antibody therapy is the use of monoclonal antibodies (or mAb) to specifically bind to target cells or proteins. This may then stimulate the patient s immune system to attack those cells.… …   Wikipedia

  • Humanized antibody — Humanized antibodies or chimeric antibodies are a type of monoclonal antibody that have been synthesized using recombinant DNA technology to circumvent the clinical problem of immune response to foreign antigens. The standard procedure of… …   Wikipedia

  • Monoclonal antibodies — A general representation of the methods used to produce monoclonal antibodies. Monoclonal antibodies (mAb or moAb) are monospecific antibodies that are the same because they are made by identical immune cells that are all clones of a unique… …   Wikipedia

  • humanized antibody — Usually a mouse monoclonal antibody directed against a target of particular therapeutic value that has been modified to have all regions except the antigen binding portion substituted by human immunoglobulin domains. The procedure should make the …   Dictionary of molecular biology

  • humanized — verb a monoclonal antibody derived from a mostly human source …   Wiktionary

  • Nomenclature of monoclonal antibodies — List of stems for monoclonal antibody nomenclature[1][2][3] …   Wikipedia

  • Nimotuzumab — ? Monoclonal antibody Type Whole antibody Source Humanized (from mouse) Target EGFR Clinical data Pregnancy cat.  ? Legal status …   Wikipedia

  • Visilizumab — ? Monoclonal antibody Type Whole antibody Source Humanized (from mouse) Target CD3 receptor Clinical data Pregnancy cat.  ? Legal status …   Wikipedia

  • Ocrelizumab — ? Monoclonal antibody Type Whole antibody Source Humanized (from mouse) Target CD20 Clinical data Pregnancy cat.  ? Legal status …   Wikipedia

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