histone deacetylase

HDAC. An enzyme that changes the way histone binds to DNA. HDAC inhibitors are being studied as a treatment for cancer.

English dictionary of cancer terms . 2015.

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  • Histone deacetylase — Histone deacetylases (HDAC) (EC number 3.5.1) are a class of enzymes that remove acetyl groups from an ε N acetyl lysine amino acid on a histone. Its action is opposite to that of histone acetyltransferase.ubtypesHDAC proteins are found in three… …   Wikipedia

  • Histone deacetylase 2 — Histone deacetylase 2, also known as HDAC2, is a human gene. PBB Summary section title = summary text = This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes and… …   Wikipedia

  • Histone deacetylase 5 — Histone deacetylase 5, also known as HDAC5, is a human gene.cite web | title = Entrez Gene: HDAC5 histone deacetylase 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=10014| accessdate = ] PBB Summary… …   Wikipedia

  • histone deacetylase — noun Any of a class of enzymes that remove acetyl groups from lysine amino acids in proteins, especially the histone proteins of the nucleus …   Wiktionary

  • histone deacetylase — his·tone de·ace·tyl·ase (hisґtōn de″ə seґtil ās) [EC 3.5.1.48] any of a group of enzymes that remove an acetyl group from histone and thus allow it to bind DNA and inhibit transcription …   Medical dictionary

  • Histone deacetylase inhibitor — Histone deacetylase inhibitors (HDAC inhibitors, HDI) are a class of compounds that interfere with the function of histone deacetylase.Cellular Biochemistry / PharmacologyTo carry out gene expression, a cell must control the coiling and uncoiling …   Wikipedia

  • histone deacetylase inhibitor — HDAC inhibitor. A substance that causes a chemical change that stops tumor cells from dividing. HDAC inhibitors are being studied in the treatment of cancer. Also called HDAC inhibitor …   English dictionary of cancer terms

  • Histone — In biology, histones are the chief protein components of chromatin. They act as spools around which DNA winds, and they play a role in gene regulation. Without histones, the unwound DNA in chromosomes would be very long. For example, each human… …   Wikipedia

  • Histone-Modifying Enzymes — The packaging of the eukaryotic genome into highly condensed chromatin makes it inaccessible to the factors required for gene transcription, DNA replication, recombination and repair. Eukaryotes have developed intricate mechanisms to overcome… …   Wikipedia

  • Histone acetyltransferase — protein Name=Histone Acetyltransferase 1 caption= width= HGNCid=4821 Symbol=HAT1 AltSymbols= EntrezGene=8520 OMIM=603053 RefSeq=NM 003642 UniProt=O14929 PDB= ECnumber=2.3.1.48 Chromosome=2 Arm=q Band=31.2 33.1 LocusSupplementaryData=Histone… …   Wikipedia

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